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Pyrazole, pyrazolone and enaminonitrile pyrazole derivatives: Synthesis, characterization and potential in corrosion inhibition and antimicrobial applications
Journal of Molecular Liquids ( IF 5.3 ) Pub Date : 2018-01-04 , DOI: 10.1016/j.molliq.2017.12.156
Galal H. Sayed , Mohammad E. Azab , Kurls E. Anwer , Mahamad Abdel Raouf , Nabel A. Negm

Six pyrazole and pyrazolone derivatives namely: 3-amino-1-phenyl-5-pyrazolone (1), 3-amino-1-(2,4-dinitrophenyl)-5-pyrazolone (2), 1H-pyrazole-3,5-diamine-4-(2-phenyldiazenyl) (3), 1-phenyl pyrazole-3, 5-diamine, 4-[2-(4-methylphenyl) diazenyl] (4), 1H-pyrazole-3,5-diamine, 4-[2-(4-methylphenyl) diazenyl] (5), 5-amino-1,3–diphenyl-1H-pyrazolecarbonitrile (6) were synthesized and evaluated as corrosion inhibitors for copper alloy dissolution in basic medium. Corrosion inhibition evaluation was performed using weight loss, polarization and electrochemical impedance measurements. The results showed that the prepared compounds have high efficiency as corrosion inhibitors for dissolution prevention of copper in NH4OH solution at pH of 9. The prepared compounds were evaluated for their antimicrobial activities against gram positive and gram negative bacteria using inhibition zone diameter measurements. The results revealed that the synthesized compounds have higher antibacterial activities than the conventional bactericide agents. The results of the antimicrobial activities and the corrosion inhibition tendencies of these compounds were correlated to their chemical structures.



中文翻译:

吡唑,吡唑啉酮和对氨基腈吡唑衍生物:合成,表征以及在缓蚀和抗菌应用中的潜力

六种吡唑和吡唑啉酮衍生物,分别是:3-氨基-1-苯基-5-吡唑啉酮(1),3-氨基-1-(2,4-二硝基苯基)-5-吡唑啉酮(2),1H-吡唑-3,5 -二胺-4-(2-苯基二氮烯基)(3),1-苯基吡唑-3、5-二胺,4- [2-(4-甲基苯基)二氮烯基](4),1H-吡唑-3,5-二胺合成了4- [2-(4-甲基苯基)二氮烯基](5),5-氨基-1,3-二苯基-1H-吡唑甲腈(6),并作为腐蚀抑制剂用于铜合金在碱性介质中的溶解。使用重量损失,极化和电化学阻抗测量进行腐蚀抑制评估。结果表明,所制备的化合物作为缓蚀剂对防止铜在NH 4中的溶解具有很高的效率。在pH值为9的OH溶液中。使用抑制区直径测量评估制备的化合物对革兰氏阳性和革兰氏阴性细菌的抗菌活性。结果表明,所合成的化合物具有比常规杀菌剂更高的抗菌活性。这些化合物的抗菌活性和腐蚀抑制趋势的结果与其化学结构相关。

更新日期:2018-01-04
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