Due to the great biological importance of β-glucuronidase inhibitors, here in this study, we have synthesized a library of novel benzothiazole derivatives (1–30), characterized by different spectroscopic methods and evaluated for β-glucuronidase inhibitory potential. Among the series sixteen compounds i.e. 1–6, 8, 9, 11, 14, 15, 20–23 and 26 showed outstanding inhibitory potential with IC₅₀ value ranging in between 16.50 ± 0.26 and 59.45 ± 1.12 when compared with standard d-Saccharic acid 1,4-lactone (48.4 ± 1.25 µM). Except compound 8 and 23 all active analogs showed better potential than the standard. Structure activity relationship has been established.

由于大生物重要性β葡糖醛酸酶抑制剂，这里在本研究中，我们已经合成了新颖的苯并噻唑衍生物（库1 - 30），其特征在于由不同的光谱方法和评价β葡萄糖醛酸酶抑制潜力。间的系列16个的化合物，即 1 - 6，8，9，11，14，15，20 - 23和26显示出杰出的抑制潜力与IC ₅₀与标准d-蔗糖酸1,4-内酯（48.4±1.25 µM）相比，该值在16.50±0.26和59.45±1.12之间。除化合物8和23外，所有活性类似物均显示出比标准品更好的电势。已建立结构活动关系。