Using DNA strand displacement to control interactions in DNA-grafted colloids,Soft Matter

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Using DNA strand displacement to control interactions in DNA-grafted colloids
Soft Matter ( IF 2.9 ) Pub Date : 2018-01-04 00:00:00 , DOI: 10.1039/c7sm01722g
Emily W. Gehrels _{1,

2,

3,

4,

5} , W. Benjamin Rogers _{1,

2,

3,

4,

5} , Vinothan N. Manoharan _{1,

2,

3,

4,

5}

Affiliation

Grafting DNA oligonucleotides to colloidal particles leads to specific, reversible interactions between those particles. However, the interaction strength varies steeply and monotonically with temperature, hindering the use of DNA-mediated interactions in self-assembly. We show how the dependence on temperature can be modified in a controlled way by incorporating DNA strand-displacement reactions. The method allows us to make multicomponent systems that can self-assemble over a wide range of temperatures, invert the dependence on temperature to design colloidal systems that melt upon cooling, controllably transition between structures with different compositions, or design systems with multiple melting transitions. This wide range of behaviors can be realized simply by adding a small number of DNA strands to the solution, making the approach modular and straightforward to implement. We conclude with practical considerations for designing systems of DNA-mediated colloidal interactions.

中文翻译：

使用DNA链置换控制DNA嫁接胶体中的相互作用

将DNA寡核苷酸嫁接到胶体颗粒上会导致这些颗粒之间发生特定的，可逆的相互作用。但是，相互作用强度随温度急剧单调变化，从而阻碍了DNA介导的相互作用在自组装中的使用。我们展示了如何通过结合DNA链置换反应以受控方式修改对温度的依赖性。该方法使我们能够制造出可以在很宽的温度范围内自组装的多组分系统，消除对温度的依赖性，从而设计出在冷却时熔化的胶体系统，可控地转变具有不同成分的结构之间的胶体系统，或设计出具有多个熔化转变的系统。只需将少量DNA链添加到溶液中，即可实现如此广泛的行为，使该方法模块化且易于实现。我们以设计DNA介导的胶体相互作用系统的实际考虑作为结论。

更新日期：2018-01-04

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