An elimination/Heck coupling/allylation cascade reaction: synthesis of 2,3-dihydrobenzofurans from allenoate adducts,Chemical Communications

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An elimination/Heck coupling/allylation cascade reaction: synthesis of 2,3-dihydrobenzofurans from allenoate adducts
Chemical Communications ( IF 4.3 ) Pub Date : 2018-01-04 00:00:00 , DOI: 10.1039/c7cc07435b
Jianguo Yang _{1,

2,

3,

4} , Hanjie Mo _{1,

2,

3,

4} , Haijian Wu _{4,

5,

6,

7} , Dongdong Cao _{1,

2,

3,

4} , Chengmin Pan _{1,

2,

3,

4} , Zhiming Wang _{1,

2,

3,

4,

5}

Affiliation

A highly regio- and stereoselective Pd-catalyzed cascade reaction of allenoate adducts has been developed. Various allenoate adducts of phosphine-catalyzed addition of allenoates are found to be efficient substrates for the preparation of 2,3-dihydrobenzofuran. It is the first example of allenoate adducts used as ideal and practical precursors of hard-to-get functionalized 1,3-butadienes for heterocycle synthesis.

中文翻译：

消除/ Heck偶联/烯丙基化级联反应：由脲基甲酸酯加合物合成2,3-二氢苯并呋喃

已经开发了高度区域和立体选择性的钯催化的脲基酸酯加合物的级联反应。发现膦催化的烯丙酸酯的加成的各种烯丙酸酯加合物是制备2，3-二氢苯并呋喃的有效底物。这是脲醛酸酯加合物用作杂环合成中难以获得的功能化1,3-丁二烯的理想和实用前体的第一个例子。

更新日期：2018-01-31

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