Vascular barrier function is controlled at cell–cell junctions in response to blood flow, but how vascular endothelial cells sense and respond to flow remains to be understood. A recent study describes a flow-sensing pathway involving non-canonical Notch and cadherin signaling that sheds new light on mechanisms controlling the endothelial barrier.

中文翻译：

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开创血管流量感测的新途径

血管屏障功能在细胞-细胞连接处响应血流而受到控制，但是血管内皮细胞如何感知和响应血流仍有待了解。最近的一项研究描述了涉及非典型Notch和钙黏着蛋白信号传导的流量感应途径，为控制内皮屏障的机制提供了新的思路。