In this study, we developed a nanoporous biodegradable mesh, bioinspired by the spider web, which is prepared via electrospinning using γ-cyclodextrin (γ-CD) conjugated with phenylacetic acid (PA), named γ-CDP. The resulting γ-CDP has a microfibrous or microspherical shape and contains drug trap meshlike γ-CD pores. These γ-CDP micromeshes (microspheres or microfibers) enable efficient drug capture and drug transport into deep γ-CDP nanocompartments or out of the γ-CDP web, resulting in a driving domain for a 4-week drug release. When used to deliver chemotherapeutic agents to xenografted tumors, the γ-CDP implants caused nearly complete tumor regression for 4 weeks after single administration. This strategy of a drug trap biodegradable mesh (with low density) will make drug containers uniquely attractive for the development of therapeutic implants and functional biomedical devices.

在这项研究中，我们开发了一种纳米多孔的可生物降解的网片，受到蜘蛛网的启发，该网片是通过使用与苯乙酸（PA）共轭的名为γ-CDP的γ-环糊精（γ-CD）进行静电纺丝而制备的。所得的γ-CDP具有微纤维或微球形的形状，并包含药物捕获网状的γ-CD孔。这些γ-CDP微网（微球或微纤维）能够有效地捕获药物并将药物输送到深γ-CDP纳米隔室中或从γ-CDP网中运出，从而导致4周药物释放的驱动域。当用于将化学治疗剂递送至异种移植肿瘤时，γ-CDP植入物在单次给药后4周内几乎导致了肿瘤的完全消退。