The aim of this study was to determine protective effects of curcumin on some haematological values and oxidant/antioxidant status in Cyprinus carpio exposed to chlorpyrifos. The fish were exposed to two sublethal concentrations of chlorpyrifos (0.040 and 0.080 mg L), and curcumin (100 mg per kg of fish weight) was simultaneously administered for 14 days. Blood and tissue (liver, kidney, and gill) samples were collected at the end of the experiment and analysed to determine the haematological profile (red blood cell count, white blood cell count, haemoglobin concentration, and haematocrit level) and oxidant/antioxidant status (malondialdehyde level and superoxide dismutase, catalase, glutathione peroxidase, and glutathione-S-transferase activities) of the fish. There was a significant decrease in the red blood cell count, the haemoglobin concentration, and the haematocrit level and a increase in the white blood cell count of CPF-treated fish. The results revealed a significant increase in the malondialdehyde levels of the groups that were exposed to CPF. Conversely, the MDA levels were significantly decreased by curcumin. Also, CPF exposure caused a significant increase in the superoxide dismutase and glutathione-S-transferase activities and a significant decrease in the catalase and glutathione peroxidase activities. However, curcumin reversed the superoxide dismutase, catalase, glutathione peroxidase, and glutathione-S-transferase activities. In conclusion, this study demonstrated that CPF had a negative effect on the haematological values and the oxidant/antioxidant status of the fish. The simultaneous administration of curcumin was neutralised CPF-induced toxicity.

这项研究的目的是确定姜黄素对鲤鱼某些血液学值和氧化剂/抗氧化剂状态的保护作用。暴露于毒死rif。将鱼暴露于两个致死浓度的毒死rif（0.040和0.080 mg L）中，同时给予姜黄素（每公斤鱼重100 mg）14天。在实验结束时收集血液和组织（肝，肾和腮）样本，并进行分析以确定血液学特征（红细胞计数，白细胞计数，血红蛋白浓度和血细胞比容水平）和氧化剂/抗氧化剂状态（鱼的丙二醛水平和超氧化物歧化酶，过氧化氢酶，谷胱甘肽过氧化物酶和谷胱甘肽S-转移酶活性）。CPF处理鱼的红细胞数量，血红蛋白浓度和血细胞比容水平显着下降，白细胞数量增加。结果显示，暴露于CPF的组的丙二醛水平显着增加。相反，姜黄素可显着降低MDA水平。而且，CPF暴露导致超氧化物歧化酶和谷胱甘肽-S-转移酶活性显着增加，并且过氧化氢酶和谷胱甘肽过氧化物酶活性显着降低。但是，姜黄素逆转了超氧化物歧化酶，过氧化氢酶，谷胱甘肽过氧化物酶和谷胱甘肽-S-转移酶的活性。总之，这项研究表明，公积金对鱼类的血液学价值和氧化/抗氧化状态具有负面影响。同时给予姜黄素可中和CPF诱导的毒性。姜黄素可显着降低MDA水平。而且，CPF暴露导致超氧化物歧化酶和谷胱甘肽-S-转移酶活性显着增加，并且过氧化氢酶和谷胱甘肽过氧化物酶活性显着降低。但是，姜黄素逆转了超氧化物歧化酶，过氧化氢酶，谷胱甘肽过氧化物酶和谷胱甘肽-S-转移酶的活性。总之，这项研究表明，公积金对鱼类的血液学价值和氧化/抗氧化状态具有负面影响。同时给予姜黄素可中和CPF诱导的毒性。姜黄素可显着降低MDA水平。而且，CPF暴露导致超氧化物歧化酶和谷胱甘肽-S-转移酶活性的显着增加以及过氧化氢酶和谷胱甘肽过氧化物酶活性的显着降低。但是，姜黄素逆转了超氧化物歧化酶，过氧化氢酶，谷胱甘肽过氧化物酶和谷胱甘肽-S-转移酶的活性。总之，这项研究表明，公积金对鱼类的血液学价值和氧化/抗氧化状态具有负面影响。同时给予姜黄素可中和CPF诱导的毒性。姜黄素逆转了超氧化物歧化酶，过氧化氢酶，谷胱甘肽过氧化物酶和谷胱甘肽-S-转移酶的活性。总之，这项研究表明，公积金对鱼类的血液学价值和氧化/抗氧化状态具有负面影响。同时给予姜黄素可中和CPF诱导的毒性。姜黄素逆转了超氧化物歧化酶，过氧化氢酶，谷胱甘肽过氧化物酶和谷胱甘肽-S-转移酶的活性。总之，这项研究表明，公积金对鱼类的血液学价值和氧化/抗氧化状态具有负面影响。同时给予姜黄素可中和CPF诱导的毒性。