Hydrogels based on chitosan/hyaluronic acid/β-sodium glycerophosphate demonstrate injectability, body temperature sensitivity, pH sensitive drug release and adhesion to cancer cell. The drug (doxorubicin) loaded hydrogel precursor solutions are injectable and turn to hydrogels when the temperature is increased to body temperature. The acidic condition (pH 4.00) can trigger the release of drug and the cancer cell (Hela) can adhere to the surface of the hydrogels, which will be beneficial for tumor site-specific administration of drug. The mechanical strength, the gelation temperature, and the drug release behavior can be tuned by varying hyaluronic acid content. The mechanisms were characterized using dynamic mechanical analysis, Fourier transform infrared spectroscopy, scanning electron microscopy and fluorescence microscopy. The carboxyl group in hyaluronic acid can form the hydrogen bondings with the protonated amine in chitosan, which promotes the increase of mechanical strength of the hydrogels and depresses the initial burst release of drug from the hydrogel.

基于壳聚糖/透明质酸/β-甘油磷酸钠的水凝胶显示出可注射性，体温敏感性，pH敏感药物释放以及对癌细胞的粘附性。载有药物（阿霉素）的水凝胶前体溶液是可注射的，当温度升高至体温时会变成水凝胶。酸性条件（pH 4.00）可以触发药物的释放，而癌细胞（Hela）可以粘附在水凝胶的表面，这对于特定于肿瘤部位的药物给药将是有益的。可以通过改变透明质酸含量来调节机械强度，胶凝温度和药物释放行为。使用动态力学分析，傅立叶变换红外光谱，扫描电子显微镜和荧光显微镜对机理进行了表征。