Although an enrichment of orally derived bacteria is reported in the gut microbiota of patients with several diseases, it is mostly unknown whether oral bacteria can colonize and induce intestinal inflammation. In a recent paper in Science, Atarashi et al.¹ from Kenya Honda's laboratory show that a subset of orally derived bacteria colonizes and persists in the gut, leading to activation of the intestinal immune system and subsequent chronic inflammation in a susceptible host. The impact of oral health status as a potential contributor to inflammatory diseases at distal sites of the body deserves consideration.

中文翻译：

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口腔与肠道的联系：离胃肠道的综合观点更近了一步？

尽管据报道在患有多种疾病的患者的肠道菌群中会出现口腔衍生细菌的富集，但口腔细菌是否可以定植并诱发肠道炎症大多是未知的。在最近发表在《科学》杂志上的一篇论文中，Atarashi 等人。^{来自肯尼亚本田实验室的1}表明，一部分口腔来源的细菌在肠道中定殖并持续存在，导致肠道免疫系统激活，随后在易感宿主中发生慢性炎症。口腔健康状况作为身体远端部位炎症性疾病的潜在促成因素的影响值得考虑。