当前位置：
X-MOL 学术
›
Biomacromolecules
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Hairy and Slippery Polyoxazoline-Based Copolymers on Model and Cartilage Surfaces
Biomacromolecules ( IF 6.2 ) Pub Date : 2018-01-11 00:00:00 , DOI: 10.1021/acs.biomac.7b01828 Giulia Morgese 1, 2 , Shivaprakash N. Ramakrishna 1 , Rok Simic 1 , Marcy Zenobi-Wong 2 , Edmondo M. Benetti 1
Biomacromolecules ( IF 6.2 ) Pub Date : 2018-01-11 00:00:00 , DOI: 10.1021/acs.biomac.7b01828 Giulia Morgese 1, 2 , Shivaprakash N. Ramakrishna 1 , Rok Simic 1 , Marcy Zenobi-Wong 2 , Edmondo M. Benetti 1
Affiliation
|
Comb-like polymers presenting a hydroxybenzaldehyde (HBA)-functionalized poly(glutamic acid) (PGA) backbone and poly(2-methyl-2-oxazoline) (PMOXA) side chains chemisorb on aminolized substrates, including cartilage surfaces, forming layers that reduce protein contamination and provide lubrication. The structure, physicochemical, biopassive, and tribological properties of PGA-PMOXA-HBA films are finely determined by the copolymer architecture, its reactivity toward the surface, i.e. PMOXA side-chain crowding and HBA density, and by the copolymer solution concentration during assembly. Highly reactive species with low PMOXA content form inhomogeneous layers due to the limited possibility of surface rearrangements by strongly anchored copolymers, just partially protecting the functionalized surface from protein contamination and providing a relatively weak lubrication on cartilage. Biopassivity and lubrication can be improved by increasing copolymer concentration during assembly, leading to a progressive saturation of surface defects across the films. In a different way, less reactive copolymers presenting high PMOXA side-chain densities form uniform, biopassive, and lubricious films, both on model aminolized silicon oxide surfaces, as well as on cartilage substrates. When assembled at low concentrations these copolymers adopt a “lying down” conformation, i.e. adhering via their backbones onto the substrates, while at high concentrations they undergo a conformational transition, assuming a more densely packed, “standing up” structure, where they stretch perpendicularly from the substrate. This specific arrangement reduces protein contamination and improves lubrication both on model as well as on cartilage surfaces.
更新日期：2018-01-11
京公网安备 11010802027423号