Regioselective C‐7 nitration of 8‐aminoquinoline amide has been achieved using tert‐butyl nitrite under metal‐free conditions at ambient temperature. The protocol is applicable to various aryl, heteroaryl as well as aliphatic carboxamides, and exhibits high functional group compatibility. The present method provides selective mononitrated quinoline derivatives. Experimental results suggest that the reaction likely proceeds through a radical pathway.

中文翻译：

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亚硝酸叔丁酯对8-氨基喹啉酰胺的区域选择性C-7硝化

在环境温度下，在无金属条件下，使用亚硝酸叔丁酯可实现8-氨基喹啉酰胺的区域选择性C-7硝化。该协议适用于各种芳基，杂芳基以及脂肪族羧酰胺，并具有较高的官能团相容性。本方法提供了选择性的单硝化喹啉衍生物。实验结果表明该反应可能通过自由基途径进行。