ortho-Amino group functionalized 2,2′-bipyridine based Ru(ii) complex catalysed alkylation of secondary alcohols, nitriles and amines using alcohols†,Organic Chemistry Frontiers

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ortho-Amino group functionalized 2,2′-bipyridine based Ru(ii) complex catalysed alkylation of secondary alcohols, nitriles and amines using alcohols†
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2018-01-03 00:00:00 , DOI: 10.1039/c7qo01061c
Bivas Chandra Roy _{1,

2,

3,

4} , Subhankar Debnath _{1,

2,

3,

4} , Kaushik Chakrabarti _{1,

2,

3,

4} , Bhaskar Paul _{1,

2,

3,

4} , Milan Maji _{1,

2,

3,

4} , Sabuj Kundu _{1,

2,

3,

4}

Affiliation

Various Ru(II) complexes bearing functionalized 2,2′-bipyridine ligands were synthesized and fully characterized. Among them, a new N6,N6′-dimethyl-2,2′-bipyridine-6,6′-diamine ligand was found to be the most electron-rich ligand as its corresponding Ru(II) complex (1a) displayed the lowest ν_co value and the highest efficiency in the β-alkylation of secondary alcohols with primary alcohols (TON = 98 860). Complex 1a also exhibited a greater reactivity in the monoalkylation of acetonitrile, α-alkylation as well as α-methylation of arylacetonitriles. Compared to the other reported systems, in α-methylation of nitriles complex 1a presented superior catalytic activity. The potential of complex 1a was extended further in N-methylation of amines using methanol as a green methylating agent.

中文翻译：

邻氨基官能化的基于2,2'-联吡啶的Ru（ii）络合物通过醇催化仲醇，腈和胺的烷基化†

合成了各种带有功能化的2,2'-联吡啶配体的Ru（II）配合物，并对其进行了充分表征。其中，发现一个新的N 6，N 6'-二甲基-2,2'-联吡啶-6,6'-二胺配体是最富电子的配体，因为它显示出相应的Ru（II）络合物（1a）仲醇与伯醇的β-烷基化反应中最低的v _co值和最高的效率（TON = 98 860）。络合物1a在乙腈的单烷基化，芳基乙腈的α-烷基化以及α-甲基化中也显示出更高的反应性。与其他已报道的系统相比，腈络合物1a的α-甲基化表现出优异的催化活性。使用甲醇作为绿色甲基化剂，在胺的N-甲基化反应中，络合物1a的潜力进一步得到扩展。

更新日期：2018-01-03

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