Tunable pH-Responsive Chitosan-Poly(acrylic acid) Electrospun Fibers,Biomacromolecules

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Tunable pH-Responsive Chitosan-Poly(acrylic acid) Electrospun Fibers
Biomacromolecules ( IF 5.5 ) Pub Date : 2018-01-12 00:00:00 , DOI: 10.1021/acs.biomac.7b01672
Rui-Yan Zhang ₁ , Ekaterina Zaslavski ₁ , Gleb Vasilyev ₁ , Mor Boas ₁ , Eyal Zussman ₁

Affiliation

The macromolecular organization in system composed of anionic poly(acrylic acid) (PAA) and cationic chitosan (Cs), with different degrees of deacetylation (DD), under extensive elongational flow, is described. Cs/PAA nanofibers were obtained, and polyelectrolyte complexation only occurred when fibers were immersed in fluid media of a certain pH. Assembled polyelectrolytes complexes formed a pH-triggered system, as demonstrated by reversible change of the swelling degree, by 3 orders of magnitude, and a change on the elastic modulus, by 2 orders of magnitude. Both the swelling degree and the elastic modulus proved sensitive to the DD of Cs. Rheological measurements showed that increased DD of Cs resulted in a decrease in viscosity of both pure Cs and precursor Cs/PAA solutions, attributed to repulsive interactions between ionized amino groups in Cs. At the same time, a DD-dependent change in balance between hydrogen bonding and ion-dipole interactions between the components in Cs/PAA, was responsible for the more pronounced viscosity decrease in these solutions.

中文翻译：

可调节pH值的壳聚糖-聚（丙烯酸）电纺纤维

描述了在大的伸长流动下，由阴离子聚丙烯酸（PAA）和阳离子脱乙酰壳多糖（Cs）组成的体系中的大分子组织，它们具有不同的脱乙酰度（DD）。获得了Cs / PAA纳米纤维，只有将纤维浸入一定pH值的流体介质中时，聚电解质才发生络合。组装的聚电解质复合物形成了一个pH触发系统，如溶胀度的可逆变化（3个数量级）和弹性模量的变化（2个数量级）所示。溶胀度和弹性模量均被证明对Cs的DD敏感。流变学测量表明，Cs DD的增加导致纯Cs和前体Cs / PAA溶液的粘度降低，这归因于Cs中离子化氨基之间的排斥相互作用。

更新日期：2018-01-12

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