The bovine serum albumin-coated magnetic nanoparticles ([email protected] NPs) were prepared as curcumin (CUR) carriers through desolvation and chemical co-precipitation process. The characteristics of CUR loaded [email protected] NPs ([email protected]@CUR NPs) were determined by X-ray diffraction (XRD), thermogravimetric analysis (TGA), fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and vibrating-sampling magnetometry (VSM) techniques. It was found that the synthesized [email protected]@CUR NPs were spherical in shape with an average size of 56 ± 11.43 nm (mean $\pm$ SD (n = 33)), ζ-potential of −10.1 mV, and good magnetic responsivity. Meanwhile, the drug content of the nanoparticles was 6.88%. These [email protected]@CUR NPs also demonstrated sustained release of CUR at 37 °C in different buffer solutions. Cellular toxicity of [email protected]@CUR NPs was studied on HFF2 cell line. Also, the cytotoxicity of [email protected]@CUR NPs towards MCF-7 breast cancer cells was investigated. The results revealed that [email protected]@CUR NPs have significant cytotoxicity activity on MCF-7 cell line.

通过去溶剂化和化学共沉淀过程，将牛血清白蛋白涂层的磁性纳米颗粒（[电子邮件保护] NPs）制备为姜黄素（CUR）载体。通过X射线衍射（XRD），热重分析（TGA），傅立叶变换红外光谱（FTIR），透射电子显微镜（TEM）确定CUR负载的[受电子邮件保护的] NP（[受电子邮件保护] @CUR NP）的特征。 ，以及振动采样磁力计（VSM）技术。发现合成的[受电子邮件保护的] @CUR NP为球形，平均尺寸为56±11.43 nm（平均$\pm$SD（n = 33）），ζ电位为-10.1 mV，并且具有良好的磁响应性。同时，纳米颗粒的药物含量为6.88％。这些[受电子邮件保护的] @CUR NP还证明了在不同缓冲液中37°C下CUR的持续释放。在HFF2细胞系上研究了[电子邮件保护的] @CUR NPs的细胞毒性。同样，研究了[电子邮件保护的] @CUR NP对MCF-7乳腺癌细胞的细胞毒性。结果表明，[电子邮件保护的] @CUR NP对MCF-7细胞系具有明显的细胞毒性活性。