Abstract The main electrospinning parameters, i.e., polymer concentration in the injectable solution, solvents used and their proportion, flow rate, voltage and distance to collector were herein systematically modified to analyse their particular influence in fibres diameter of electrospun membranes of poly(lactic acid), polycaprolactone and their mixture. As a result of this analysis, the procedures to obtain membranes of these polymers and blend with under- and above-micron-sized fibres were established, in which the solvents ratio (chloroform/methanol and dichloromethane/dimethylformamide) and voltage were found to play the major role. Moreover, the plausible differential effect of these fibres diameters (0.8 and 1.8 µm) in the controlled release of a molecule of interest was explored, using bovine serum albumin (BSA), proving that the most effective configuration for BSA release among those studied was the PLA-PCL combination in membranes of above-micron fibres diameter.

中文翻译：

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具有定制纤维直径的 PLA/PCL 电纺膜作为药物递送系统

摘要 本文系统地修改了主要的静电纺丝参数，即注射液中的聚合物浓度、所用溶剂及其比例、流速、电压和到收集器的距离，以分析它们对聚乳酸静电纺丝膜纤维直径的特殊影响。 、聚己内酯及其混合物。作为该分析的结果，建立了获得这些聚合物膜并与微米级以下和以上微米级纤维混合的程序，其中发现溶剂比（氯仿/甲醇和二氯甲烷/二甲基甲酰胺）和电压起作用主要作用。此外，使用牛血清白蛋白 (BSA) 探索了这些纤维直径（0.8 和 1.8 µm）在目标分子受控释放中的合理差异效应，