The gastroprotective activity of Hericium erinaceus polysaccharide was investigated in rats. The antioxidant activities were also evaluated. Pre-treatment of polysaccharide could reduce ethanol-induced gastric mucosal lesion and pylorus ligation-induced gastric ulcer. The polysaccharide exhibited scavenging activities of 1, 1-diphenyl-2-picryl-hydrozyl and hydroxyl radicals, and ferrous ion-chelating ability. In the pylorus ligation-induced model, gastric secretions (volume of gastric juice, gastric acid, pepsin and mucus) of ulcer rats administrated with polysaccharide were regulated. Levels of tumor necrosis factor-α and interleukins-1β in serum, and myeloperoxidase activity of gastric tissue were reduced, while antioxidant status of gastric tissue was improved. Defensive factors (nitric oxide, prostaglandin E2, epidermal growth factor) in gastric tissue were increased. These results indicate that Hericium erinaceus polysaccharide possess gastroprotective activity, and the possible mechanisms are related to its regulations of gastric secretions, improvements of anti-inflammatory and antioxidant status, as well as increments of defensive factors releases.

猴头菇的胃保护活性在大鼠中研究了多糖。还评估了抗氧化剂活性。多糖的预处理可以减少乙醇引起的胃粘膜病变和幽门结扎引起的胃溃疡。该多糖表现出1，1-二苯基-2-吡啶基-羟基和羟自由基的清除活性，以及​​亚铁离子螯合能力。在幽门结扎诱导的模型中，调节给予多糖的溃疡大鼠的胃分泌物（胃液，胃酸，胃蛋白酶和粘液的体积）。血清中肿瘤坏死因子-α和白介素-1β水平降低，胃组织髓过氧化物酶活性降低，胃组织的抗氧化状态得到改善。胃组织中的防御因子（一氧化氮，前列腺素E2，表皮生长因子）增加。猴头菇多糖具有胃保护作用，其可能的机制与其调节胃液分泌，改善抗炎和抗氧化状态以及增加防御因子的释放有关。