当前位置: X-MOL 学术Langmuir › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Modeling Biofilm Formation on Dynamically Reconfigurable Composite Surfaces
Langmuir ( IF 3.7 ) Pub Date : 2018-01-17 00:00:00 , DOI: 10.1021/acs.langmuir.7b03765
Ya Liu 1 , Anna C. Balazs 1
Affiliation  

We augment the dissipative particle dynamics (DPD) simulation method to model the salient features of biofilm formation. We simulate a cell as a particle containing hundreds of DPD beads and specify p, the probability of breaking the bond between the particle and surface or between the particles. At the early stages of film growth, we set p = 1, allowing all bonding interactions to be reversible. Once the bound clusters reach a critical size, we investigate scenarios where p = 0, so that incoming species form irreversible bonds, as well as cases where p lies in the range of 0.1–0.5. Using this approach, we examine the nascent biofilm development on a coating composed of a thermoresponsive gel and the embedded rigid posts. We impose a shear flow and characterize the growth rate and the morphology of the clusters on the surface at temperatures above and below Tc, the volume phase transition temperature of a gel that displays lower critical solubility temperature (LCST). At temperatures above Tc, the posts effectively inhibit the development of the nascent biofilm. For temperatures below Tc, the swelling of the gel plays the dominant role and prevents the formation of large clusters of cells. Both these antifouling mechanisms rely on physical phenomena and, hence, are advantageous over chemical methods, which can lead to unwanted, deleterious effects on the environment.

中文翻译:

在动态可重构复合表面上建模生物膜形成

我们增强了耗散粒子动力学(DPD)模拟方法来建模生物膜形成的显着特征。我们将细胞模拟为包含数百个DPD珠的粒子,并指定p,即打破粒子与表面或粒子之间的键的概率。在薄膜生长的早期,我们将p设置为1,从而使所有键相互作用都是可逆的。一旦束缚簇达到临界大小,我们将研究p = 0的情况,以便进入的物种形成不可逆的键,以及p的情况在0.1-0.5的范围内。使用这种方法,我们检查了由热响应性凝胶和嵌入的刚性柱组成的涂层上新生的生物膜的发育。我们施加剪切流,并在高于和低于T c的温度下表征表面上簇的生长速率和形态,T c是显示较低临界溶解温度(LCST)的凝胶的体积相变温度。在高于T c的温度下,这些柱有效地抑制了新生生物膜的发育。对于低于T c的温度,凝胶的溶胀起主要作用,并防止形成大的细胞簇。这两种防污机制都依赖于物理现象,因此,它们优于化学方法,化学方法会导致对环境的有害有害影响。
更新日期:2018-01-17
down
wechat
bug