With the increasing morbidity and mortality of invasive fungal infections and the emergence of severe antifungal drug resistance, new drug targets and novel antifungal agents are urgently needed. Recently, better understanding of fungal pathogenesis has contributed to the rapid emergence of potential antifungal drug targets. This perspective aims to provide a comprehensive review of new antifungal targets and of medicinal chemistry efforts toward inhibitor discovery. Particular focus will be placed on the druggability of the targets and their potential to treat resistant fungal infections. Innovative strategies for the next generation of antifungal therapy, such as virulence factors, protein–protein interactions, and immune response-based proteins, will also be highlighted.

中文翻译：

---

治疗耐药性真菌感染的新目标

随着侵入性真菌感染的发病率和死亡率的增加以及严重的抗真菌药物耐药性的出现，迫切需要新的药物靶标和新型的抗真菌剂。近来，对真菌发病机理的更好理解促进了潜在的抗真菌药物靶标的快速出现。该观点旨在全面综述新的抗真菌靶标以及药物化学对抑制剂发现的努力。将特别关注目标的可药物性及其在治疗耐药性真菌感染中的潜力。下一代抗真菌治疗的创新策略，例如毒力因子，蛋白质-蛋白质相互作用和基于免疫反应的蛋白质，也将得到重点介绍。