Abstract Analysis of samples available in small volumes is an important challenge in analytical chemistry. Therefore, we have dealt with the development of a new miniaturized micro-volume voltammetric cell (MVVC) for the determination of reducible organic compounds in micro-volumes (20–50 μL). The MVVC is composed of two compartments, a micro-volume compartment, where the analyte is present along with the working electrode, separated by means of an agar membrane (about 2 mm) from a large-volume compartment containing the supporting electrolyte and the counter and reference electrodes. This MVVC was tested by the determination of sodium anthraquione-2-sulfonate as a model substance for structurally similar anthraquinone-based anti-cancer drugs. Using differential pulse voltammetry at a polished silver solid amalgam electrode, the following analytical parameters were obtained: linear dynamic range from 1 μmol L − 1 to 1 mmol L − 1 , repeatability of 0.7% (on the concentration level 0.1 mmol L − 1 ), and limit of detection of 0.15 μmol L − 1 .

中文翻译：

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使用琼脂膜进行阴极伏安法的微型伏安法池

摘要 分析小体积样品是分析化学中的一项重要挑战。因此，我们开发了一种新型微型微体积伏安法电池 (MVVC)，用于测定微体积 (20–50 μL) 中的可还原有机化合物。MVVC 由两个隔室组成，一个微体积隔室，其中分析物与工作电极一起存在，通过琼脂膜（约 2 毫米）与包含支持电解质和计数器的大容量隔室隔开和参比电极。通过测定蒽醌-2-磺酸钠作为结构相似的基于蒽醌的抗癌药物的模型物质来测试该MVVC。在抛光的银固体汞合金电极上使用差分脉冲伏安法，