Metal-free regioselective hydrochlorination of unactivated alkenes via a combined acid catalytic system,Green Chemistry

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Metal-free regioselective hydrochlorination of unactivated alkenes via a combined acid catalytic system
Green Chemistry ( IF 9.3 ) Pub Date : 2018-01-02 00:00:00 , DOI: 10.1039/c7gc03665e
Shengzong Liang ₁ , Gerald B Hammond ₁ , Bo Xu ₂

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A combined acid HCl/DMPU-acetic acid catalytic system was used in the hydrochlorination of a wide range of unactivated alkenes. This hydrochlorination strategy is remarkably greener than previous reported methods in terms of high atom efficiency, no toxic waste generated and metal-free process. The higher efficiency, compared with other commercially available HCl reagents, was augmented by the good regioselectivity and functionality tolerance found. A stepwise mechanism for this hydrochlorination process was proposed based on kinetic studies.

中文翻译：

通过组合酸催化系统对未活化烯烃进行无金属区域选择性氢氯化

组合式酸性 HCl/DMPU-乙酸催化系统用于多种未活化烯烃的氢氯化反应。这种氢氯化策略在原子效率高、不产生有毒废物和无金属过程方面比以前报道的方法更加环保。与其他市售 HCl 试剂相比，由于良好的区域选择性和功能耐受性，效率更高。基于动力学研究，提出了该氢氯化过程的逐步机理。

更新日期：2018-02-06

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