Off-target binding in the basal ganglia is commonly observed in the ¹⁸F-AV-1451 PET studies of the elderly. We sought to investigate the relationship between this phenomenon in the basal ganglia and iron accumulation using iron-sensitive R₂* MRI. Methods: Fifty-nine healthy controls and 61 patients with Alzheimer disease and mild cognitive impairment underwent ¹⁸F-AV-1451 PET and R₂* MRI studies. A correlation analysis was performed for age, ¹⁸F-AV-1451 binding, and R₂* values. Results: There was an age-related increase in both ¹⁸F-AV-1451 binding in the basal ganglia and R₂* values in the putamen in both the controls and the Alzheimer disease/mild cognitive impairment patients. ¹⁸F-AV-1451 binding in the basal ganglia increased with R₂* values. Conclusion: Off-target ¹⁸F-AV-1451 binding in the basal ganglia is associated with the age-related increases in iron accumulation. Postmortem studies are required to further investigate the nature of this association.

在老年人的¹⁸ F-AV-1451 PET研究中通常观察到基底节中的脱靶结合。我们试图使用铁敏感的R ₂ * MRI来研究基底神经节中这种现象与铁蓄积之间的关系。方法： 59名健康对照者和61例阿尔茨海默氏病和轻度认知障碍患者接受了^18项F-AV-1451 PET和R ₂ * MRI研究。进行了年龄，¹⁸ F-AV-1451结合和R ₂ *值的相关性分析。结果：基底节和R _2中¹⁸ F-AV-1451的结合均与年龄有关*对照和阿尔茨海默氏病/轻度认知障碍患者的壳膜中的值。基底神经节中的¹⁸ F-AV-1451结合随着R ₂ *值的增加而增加。结论：基底神经节中脱靶的¹⁸ F-AV-1451结合与年龄相关的铁积累增加有关。需要进行事后研究，以进一步调查这种关联的性质。