8-Hydroxy-2′-deoxyguanosine (8-OHdG), a product of oxidative DNA damage, which has been used as a sensitive and reliable marker of oxidative stress and carcinogenesis, is found in high levels in biological fluids of leukemia patients. A reliable screening method based on pattern recognition of 8-OHdG using stochastic sensors designed with graphene materials decorated with nanoparticles of TiO₂Ag or TiO₂Au was developed. 5,10,15,20-Tetraphenyl-21H,23H porphyrin (P), 2,6-bis((E)-2-(furan-2-yl)vinyl)-4-(4,6,8-trimethylazulen-1-yl)pyridine (Py1), and 2,6-bis((E)-2-(thiophen-3-yl)vinyl)-4-(4,6,8-trimethylazulen-1-yl)pyridine (Py2) were used as modifiers of the graphene paste in the design of sensors. The screening method used for pattern recognition was developed for two pH values accordingly with the nature of the biological fluid to be screened: pH = 3.02 for urine samples and pH = 7.49 for whole blood samples. High sensitivities and low limits of determination for 8-OHdG obtained at both pH values favored the early detection of leukemia. Recoveries over 98.00% with RSD (%) values lower than 1.00% proved the reliability of the proposed screening method.

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在白血病患者的生物体液中发现了高含量的8-羟基2'-脱氧鸟嘌呤（8-OHdG），氧化DNA损伤的产物已被用作氧化应激和致癌作用的敏感而可靠的标记。一种基于8-OHdG模式识别的可靠筛选方法，该方法是使用由TiO ₂ Ag或TiO ₂纳米粒子装饰的石墨烯材料设计的随机传感器金被开发出来。5,10,15,20-四苯基-21H，23H卟啉（P），2,6-双（（E）-2-（呋喃-2-基）乙烯基）-4-（4,6,8-三甲基az -1-基）吡啶（Py1）和2,6-双（（E）-2-（噻吩-3-基）乙烯基）-4-（4,6,8-三甲基methyl烯-1-基）吡啶（ Py2）在传感器设计中用作石墨烯糊的改性剂。因此，针对两个pH值开发了用于模式识别的筛选方法，以适应要筛选的生物流体的性质：尿液样品的pH = 3.02，全血样品的pH = 7.49。在两个pH值下获得的8-OHdG的高灵敏度和低测定限有利于白血病的早期检测。回收率超过98.00％，RSD（％）值低于1.00％，证明了所提出筛选方法的可靠性。

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