Rationale: Atherosclerotic plaque is a chronic inflammatory disorder involving lipid accumulation within arterial walls. In particular, macrophages mediate plaque progression and rupture. While PPARγ agonist is known to have favorable pleiotropic effects on atherogenesis, its clinical application has been very limited due to undesirable systemic effects. We hypothesized that the specific delivery of a PPARγ agonist to inflamed plaques could reduce plaque burden and inflammation without systemic adverse effects.

中文翻译：

---

通过体内连续光学成像评估靶向PPARɣ活化对发炎的高危斑块的治疗作用

原理：动脉粥样硬化斑块是一种慢性炎性疾病，涉及脂质在动脉壁内的蓄积。特别地，巨噬细胞介导斑块进展和破裂。尽管已知PPARγ激动剂对动脉粥样硬化具有有利的多效性作用，但由于不良的全身作用，其临床应用受到很大限制。我们假设，PPARγ激动剂向发炎斑块的特异性递送可以减轻斑块负担和炎症，而不会产生全身性不良反应。