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Exosomes from human umbilical cord blood accelerate cutaneous wound healing through miR-21-3p-mediated promotion of angiogenesis and fibroblast function
Theranostics ( IF 12.4 ) Pub Date : 2018-01-01 , DOI: 10.7150/thno.21234
Yin Hu , Shan-Shan Rao , Zhen-Xing Wang , Jia Cao , Yi-Juan Tan , Juan Luo , Hong-Ming Li , Wei-She Zhang , Chun-Yuan Chen , Hui Xie

The application of blood plasma for soft tissue wound healing is receiving much more attention recently. Exosomes are critical paracrine mediators that can be obtained from biological fluids including plasma and be able to induce regenerative effects by transferring bioactive molecules such as microRNAs (miRNAs). This study aimed to investigate the effects of exosomes from human umbilical cord blood plasma (UCB-Exos) on wound healing and to elucidate the underlying mechanism.

中文翻译:

来自人类脐带血的外泌体通过miR-21-3p介导的血管生成和成纤维细胞功能的促进来加速皮肤伤口愈合

血浆在软组织伤口愈合中的应用近来受到越来越多的关注。外泌体是重要的旁分泌介体,可以从包括血浆在内的生物液体中获得,并能够通过转移诸如microRNA(miRNA)等生物活性分子来诱导再生作用。这项研究旨在调查人脐带血血浆(UCB-Exos)的外泌体对伤口愈合的影响并阐明其潜在机制。
更新日期:2018-01-01
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