Background and Aims: Esophageal squamous cell carcinoma (ESCC), a major histologic subtype of esophageal cancer, is increasing in incidence, but the genetic underpinnings of this disease remain unexplored. The aim of this study is to identify the recurrent genetic changes, elucidate their roles and discover new biomarkers for improving clinical management of ESCC.

中文翻译：

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RHCG通过抑制NF-κB信号传导和MMP1表达抑制食管鳞癌的致瘤性和转移。

背景与目的：食管鳞癌（ESCC）是食管癌的主要组织学亚型，其发病率正在增加，但该病的遗传基础尚待探索。这项研究的目的是确定复发的遗传变化，阐明其作用并发现新的生物标记物，以改善ESCC的临床管理。