Rationale: HSV is one of the most widespread human viral pathogens. HSV-1 infects a large portion of the human population and causes severe diseases. The current clinical treatment for HSV-1 is based on nucleoside analogues, the use of which is limited due to drug resistance, side effects and poor bioavailability. AMPs have been identified as potential antiviral agents that may overcome these limitations. Therefore, we screened anti-HSV-1 peptides from a scorpion-derived AMP library and engineered one candidate into a histidine-rich peptide with significantly improved antiviral activity and development potential.

中文翻译：

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蝎子多肽的组氨酸富集修饰可提高生物利用度和对HSV-1的抑制活性。

理由： HSV是最广泛的人类病毒病原体之一。HSV-1感染了很大一部分人口，并导致了严重的疾病。HSV-1的当前临床治疗基于核苷类似物，由于耐药性，副作用和不良的生物利用度，其使用受到限制。AMP被确定为可以克服这些局限性的潜在抗病毒药物。因此，我们从蝎子来源的AMP库中筛选了抗HSV-1肽，并将一种候选物改造为富含组氨酸的肽，具有显着提高的抗病毒活性和发展潜力。