Background and Aims: Down-regulation of GPx3 accelerated hepatic senescence, which further caused overwhelming inflammation and severe liver graft injury. MSCs derived from human induced pluripotent stem cells (hiPSC-MSCs) have been developed as more efficient delivery vehicle with the property of injury tropism. Here, we aimed to explore the suppressive role of GPx3 in hepatic IR injury using novel delivery system of hiPSC-MSCs.

中文翻译：

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hiPSC-MSC传递的谷胱甘肽过氧化物酶3通过抑制肝衰老改善了肝IR损伤。

背景与目的： GPx3的下调会加速肝脏衰老，进而引起严重的炎症和严重的肝移植损伤。源自人类诱导的多能干细胞（hiPSC-MSC）的MSC已被开发为具有损伤嗜性的更有效的递送载体。在这里，我们旨在探索新型的hiPSC-MSCs递送系统对GPx3在肝脏IR损伤中的抑制作用。