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An Albumin-binding Polypeptide Both Targets Cytotoxic T Lymphocyte Vaccines to Lymph Nodes and Boosts Vaccine Presentation by Dendritic Cells
Theranostics ( IF 12.4 ) Pub Date : 2018-01-01 , DOI: 10.7150/thno.21691
Peng Wang , Peng Zhao , Shuyun Dong , Tiefeng Xu , Xiao He , Mingnan Chen

Rationale: Albumin-binding carriers have been shown to target cytotoxic T lymphocyte (CTL) vaccines to lymph nodes (LNs) and improve the efficacy of the vaccines. However, it was not clear whether the improved efficacy is solely due to the LN targeting, which prompted this study.

中文翻译:

白蛋白结合多肽既可将细胞毒性T淋巴细胞疫苗靶向淋巴结,又可促进树突状细胞疫苗的提供。

原理:结合白蛋白的载体已被证明可将细胞毒性T淋巴细胞(CTL)疫苗靶向淋巴结(LNs),并提高疫苗的功效。但是,尚不清楚提高疗效是否仅归因于LN靶向,这促使了这项研究。
更新日期:2018-01-01
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