The medial frontal cortex, including anterior midcingulate cortex, has been linked to multiple psychological domains, including cognitive control, pain, and emotion. However, it is unclear whether this region encodes representations of these domains that are generalizable across studies and subdomains. Additionally, if there are generalizable representations, do they reflect a single underlying process shared across domains or multiple domain-specific processes? We decomposed multivariate patterns of functional MRI activity from 270 participants across 18 studies into study-specific, subdomain-specific, and domain-specific components and identified latent multivariate representations that generalized across subdomains but were specific to each domain. Pain representations were localized to anterior midcingulate cortex, negative emotion representations to ventromedial prefrontal cortex, and cognitive control representations to portions of the dorsal midcingulate. These findings provide evidence for medial frontal cortex representations that generalize across studies and subdomains but are specific to distinct psychological domains rather than reducible to a single underlying process.

中文翻译：

---

内侧额叶皮层中疼痛，认知控制和负面情绪的一般化表示。

内侧额叶皮层（包括前中扣带皮层）已与多个心理领域相关联，包括认知控制，疼痛和情绪。但是，尚不清楚该区域是否编码了这些域的表示，这些表示可在研究和子域中推广。此外，如果存在可概括的表示形式，它们是否反映了跨域共享的单个基础流程或多个特定于域的流程？我们将来自18个研究的270名参与者的功能性MRI活动的多变量模式分解为研究特定，亚域特定和域特定的组件，并确定了潜伏的多变量表示形式，这些表示形式遍及子域但特定于每个域。疼痛表现局限于前中齿皮层，腹侧前额叶皮层的负性情绪表征，背侧中脉的部分的认知控制表征。这些发现为内侧额叶皮层表征提供了证据，这些表征在研究和子领域中普遍存在，但特定于不同的心理领域，而不是可归结为单个基础过程。