Nanozyme Decorated Metal–Organic Frameworks for Enhanced Photodynamic Therapy,ACS Nano

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Nanozyme Decorated Metal–Organic Frameworks for Enhanced Photodynamic Therapy
ACS Nano ( IF 15.8 ) Pub Date : 2018-01-05 00:00:00 , DOI: 10.1021/acsnano.7b07746
Yan Zhang _{1,

2} , Faming Wang _{1,

2} , Chaoqun Liu _{1,

2} , Zhenzhen Wang _{1,

2} , LiHua Kang ₃ , Yanyan Huang _{1,

2} , Kai Dong ₁ , Jinsong Ren ₁ , Xiaogang Qu ₁

Affiliation

Metal–organic frameworks (MOFs) have been used for photodynamic therapy (PDT) of cancers by integrating photosensitizers, which cause cytotoxic effects on cancer cells by converting tumor oxygen into reactive singlet oxygen (¹O₂). However, the PDT efficiency of MOFs is severely limited by tumor hypoxia. Herein, by decorating platinum nanozymes on photosensitizer integrated MOFs, we report a simple yet versatile strategy for enhanced PDT. The platinum nanoparticles homogeneously immobilized on MOFs possess high stability and catalase-like activity. Thus, our nanoplatform can facilitate the formation of ¹O₂ in hypoxic tumor site via H₂O₂-activated evolvement of O₂, which can cause more serious damage to cancer cells. Our finding highlights that the composites of nanozymes and MOFs have the potential to serve as efficient agents for cancer therapy, which will open an avenue of nanozymes and MOFs toward biological applications.

中文翻译：

纳米酶修饰的金属有机框架，可增强光动力疗法

金属有机骨架（MOF）已通过整合光敏剂用于癌症的光动力疗法（PDT），光敏剂通过将肿瘤氧转化为活性单线态氧（¹ O ₂）对癌细胞产生细胞毒性作用。但是，MOFs的PDT效率受到肿瘤缺氧的严重限制。在本文中，通过在光敏剂集成的MOF上装饰铂纳米酶，我们报告了一种简单而通用的增强PDT的策略。均匀固定在MOF上的铂纳米粒子具有很高的稳定性和过氧化氢酶样活性。因此，我们的纳米平台可以通过H ₂ O ₂促进缺氧肿瘤部位¹ O ₂的形成激活的O ₂释放，可能对癌细胞造成更严重的损害。我们的发现突出表明，纳米酶和MOF的复合物具有用作癌症治疗有效药物的潜力，这将为生物应用打开纳米酶和MOF的途径。

更新日期：2018-01-05

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