This study investigated the accumulation pattern and biological effects (genotoxicity and histopathology) to adult zebrafish (male and female) exposed to a nominal waterborne concentration of 20 μg L⁻¹ of depleted uranium (DU) for 28 days followed by 27 days of depuration. Accumulation pattern showed that (i) DU accumulated in brain, (ii) levels in digestive tract were higher than those measured in gills and (iii) levels remained high in kidney, brain and ovary despite the 27 days of depuration period. Genotoxicity, assessed by comet assay, was significant not only during DU exposure, but also during depuration phase. Gonads, in particular the testes, were more sensitive than gills. The histology of gonads indicated severe biological damages in males. This study improved knowledge of ecotoxic profile of uranium, for which a large range of biological effects has already been demonstrated.

这项研究调查了暴露于标称水性浓度为20μgL ^-1的成年斑马鱼（雄性和雌性）的积累模式和生物学效应（遗传毒性和组织病理学）的贫铀（DU）处理28天，然后进行纯净27天。积累模式显示：尽管经过了27天的净化期，但（i）脑中DU积累，（ii）消化道中的DU水平高于g测量的水平，并且（iii）肾脏，脑和卵巢中的DU水平仍然很高。通过彗星分析评估的遗传毒性，不仅在DU暴露期间很明显，而且在净化阶段也很重要。性腺，特别是睾丸，比than更敏感。性腺的组织学表现为男性严重的生物学损伤。这项研究提高了铀的生态毒性特征的知识，为此已经证明了其广泛的生物学效应。