We thank Obeid and Pietrzik¹ for their letter concerning our recent article.² The authors make a number of points to explain how our results reflect reverse causation—that participants in the Vitamins and Lifestyle (VITAL) study were at greater risk for developing cancer (or lung cancer, specifically) and therefore began using supplements. We hope that our response is instructive.

中文翻译：

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回复R. Obeid等

我们感谢Obeid和Pietrzik ¹关于我们最近的文章的来信。²作者提出许多观点来解释我们的结果如何反映反向因果关系-维生素和生活方式（VITAL）研究的参与者罹患癌症（特别是肺癌）的风险更大，因此开始使用补充剂。我们希望我们的回应是有益的。