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Sustainable Synthesis of Polynitroesters in the Freon Medium and their in Vitro Evaluation as Potential Nitric Oxide Donors
ACS Sustainable Chemistry & Engineering ( IF 7.1 ) Pub Date : 2018-01-19 00:00:00 , DOI: 10.1021/acssuschemeng.7b04029 Ilya V. Kuchurov 1 , Svetlana S. Arabadzhi 2 , Mikhail N. Zharkov 1 , Leonid L. Fershtat 1 , Sergei G. Zlotin 1
ACS Sustainable Chemistry & Engineering ( IF 7.1 ) Pub Date : 2018-01-19 00:00:00 , DOI: 10.1021/acssuschemeng.7b04029 Ilya V. Kuchurov 1 , Svetlana S. Arabadzhi 2 , Mikhail N. Zharkov 1 , Leonid L. Fershtat 1 , Sergei G. Zlotin 1
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A highly efficient, safe, and sustainable procedure was developed for the synthesis of various pharmacology-relevant and/or energy-rich nitroesters. It is based on nitration of corresponding alcohols with dinitrogen pentoxide in the liquid 1,1,1,2-tetrafluoroethane medium. The proposed approach is attractive for commercial applications because it offers significant advantages such as mild and clean reaction conditions, low operation pressure, available equipment, scalability, and facile fluid recycling. Structure–NO donor activity correlations were elucidated by an in vitro Griess assay for synthesized nitroesters and the obtained data may be useful for further in vivo experiments.
中文翻译：
在氟利昂介质中可持续合成聚硝基酯及其作为潜在一氧化氮供体的体外评价
开发了一种高效，安全和可持续的方法，用于合成各种与药理相关和/或能量丰富的硝基酯。它基于在液体1,1,1,2-四氟乙烷介质中用五氧化二氮将相应的醇进行硝化。所提出的方法对商业应用具有吸引力，因为它具有显着的优势，例如温和干净的反应条件，低操作压力，可用设备，可扩展性和液体回收方便。结构-NO供体活性的相关性已通过体外Griess测定法对合成的硝酸酯进行了阐明，获得的数据可能对进一步的体内实验有用。
更新日期：2018-01-19
中文翻译：
在氟利昂介质中可持续合成聚硝基酯及其作为潜在一氧化氮供体的体外评价
开发了一种高效，安全和可持续的方法，用于合成各种与药理相关和/或能量丰富的硝基酯。它基于在液体1,1,1,2-四氟乙烷介质中用五氧化二氮将相应的醇进行硝化。所提出的方法对商业应用具有吸引力，因为它具有显着的优势，例如温和干净的反应条件，低操作压力，可用设备，可扩展性和液体回收方便。结构-NO供体活性的相关性已通过体外Griess测定法对合成的硝酸酯进行了阐明，获得的数据可能对进一步的体内实验有用。
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