Described herein is a synthetic strategy for the total synthesis of (±)‐phomoidride D. This highly efficient and stereoselective approach provides rapid assembly of the carbocyclic core by way of a tandem phenolic oxidation/intramolecular Diels–Alder cycloaddition. A subsequent SmI₂‐mediated cyclization cascade delivers an isotwistane intermediate poised for a Wharton fragmentation that unveils the requisite bicyclo[4.3.1]decene skeleton and sets the stage for synthesis completion.

中文翻译：

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（±）-拟苯甲醛D的全合成

本文描述了一种全合成（±）-磷脂酰D的合成策略。这种高效且立体选择性的方法通过串联酚醛氧化/分子内Diels-Alder环加成法提供了碳环核的快速组装。随后的SmI ₂介导的环化级联反应提供了异沃顿中间体，可用于沃顿断裂，从而揭示必需的双环[4.3.1]癸烯骨架，并为合成完成奠定了基础。