The peptic ulcer is a gastric disorder that affects millions of people and yet they cause many side effects. In this sense, natural products represent an important alternative to the discovery of compounds with gastroprotective activity. The present work has as its objective to evaluate the antioxidant and gastroprotective activity of the Hydroalcoholic Extract of Leaves from Tocoyena formosa (Cham. & Schlecht.) K. Schum (HELTF), this being much emphasized in traditional medicine for inflammatory morbidities and gastric symptoms. For the evaluation of the antioxidant activity, FRAP and DPPH tests were carried out, and for the evaluation of the gastroprotective activity, gastric lesion induction by ethanol, acidified ethanol, indomethacin and physical barrier tests were used. Antioxidant assay of HELTF revealed an EC50 of 558.66 μM FeSO4/g and IC50 of 189.78 μg/ml for FRAP and DPPH respectively. In gastroprotective, in ethanol model, all the doses presented significant activity in comparison to controls, however, in the gastric lesion induction test by acidified ethanol and indomethacin, only the dose of 200 mg/kg presented with significance. In the physical barrier test presented evidence that protection by the formation of a protective layer associated with mucus. Concluded, therefore, that HELTF possesses antioxidant and significate gastroprotective activity.

消化性溃疡是一种胃病，影响数以百万计的人，但它们却引起许多副作用。从这个意义上讲，天然产物是发现具有胃保护活性化合物的重要替代方法。本工作的目的是评估福美To（Cham。＆Schlecht。）K. Schum（HELTF）叶片的水醇提取物的抗氧化和胃保护活性，这在炎症和胃部疾病的传统医学中已得到了很大的强调。为了评价抗氧化剂活性，进行了FRAP和DPPH测试，并且为了评价胃保护活性，使用了乙醇，酸化的乙醇，消炎痛和物理屏障试验的胃损伤诱导。HELTF的抗氧化剂测定显示EC50为558。FRAP和DPPH分别为66μMFeSO4 / g和IC50为189.78μg/ ml。在具有胃保护作用的乙醇模型中，所有剂量均与对照相比具有显着的活性，但是，在通过酸化的乙醇和消炎痛诱导的胃部病变试验中，仅200 mg / kg的剂量具有显着意义。在物理屏障测试中提供的证据表明，通过形成与粘液相关的保护层可以提供保护。因此，得出结论，HELTF具有抗氧化剂和重要的胃保护活性。在物理屏障测试中提供的证据表明，通过形成与粘液相关的保护层可以提供保护。因此，得出结论，HELTF具有抗氧化剂和重要的胃保护活性。在物理屏障测试中提供的证据表明，通过形成与粘液相关的保护层可以提供保护。因此，得出结论，HELTF具有抗氧化剂和重要的胃保护活性。