Trichothecene mycotoxins are a group of structurally related sesquiterpenoid metabolites produced by multiple Fusarium species that often contaminate cereals and threaten human and animal health. The basic structure of this mycotoxin group is a characteristic 12, 13-epoxide group, which is considered an essential functional group for toxicity. In this study, using trichothecene mycotoxin deoxynivalenol (DON) as a representative substrate, we identified a novel trichothecene deepoxidation bacterium, Eggerthella sp. DII-9 (DII-9), from chicken intestines. DII-9 can grow and transform DON over abroad range of temperatures (20–45 °C) and pH values (5–10), suggesting the possibility of developing promising future applications as feed additives. Substrate specificity analysis showed that DII-9 is capable of promoting the deepoxidation of DON, HT-2, T-2 triol and T-2 tetraol. To explore the molecular mechanisms of the de-epoxidation of trichothecenes, the complete genome of DII-9 was sequenced and characterized. Altogether, a novel detoxification bacterium for trichothecene mycotoxins was identified and characterized.

天花粉真菌毒素是一组由多种镰刀菌产生的结构相关的倍半萜类代谢物，它们经常污染谷物并威胁人类和动物健康。这种霉菌毒素基团的基本结构是特征性的12、13-环氧基团，被认为是毒性必不可少的官能团。在这项研究中，以单端孢菌素霉菌毒素脱氧雪腐烯醇（DON）为代表底物，我们鉴定了一种新颖的端孢菌素深氧化细菌Eggerthellasp。DII-9（DII-9），来自鸡肠。DII-9可以在国外的温度范围（20–45°C）和pH值（5–10）范围内生长和转化DON，这表明未来有可能发展为饲料添加剂。底物特异性分析表明，DII-9能够促进DON，HT-2，T-2三醇和T-2四醇的深度氧化。为了探索毛果霉素脱环氧化的分子机制，对DII-9的完整基因组进行了测序和表征。总体上，鉴定并鉴定了一种新的用于天花粉真菌毒素的解毒细菌。