HPLC-PDA-MS/MS analysis of Syzygium jambos leaf extract allowed the identification of 17 secondary metabolites, including flavonol glycosides, flavonol di-glycosides, and flavones as well as ellagitannins and phenolic acids. The extract showed promising antioxidant activities in different experimental models. In Caenorhabditis elegans, the extract mediated a dose dependent survival rate and decreased the intracellular ROS level and HSP-16.2 expression. In a rat model against acute CCl₄ intoxication, the extract reduced the levels of all tested liver markers ALT, AST, TB, TC, TG, and MDA and increased GSH and SOD; effects were similar to those of silymarin. In hepatocytes, pre-treatment with the extract inhibited ROS production, against the deleterious effects of sodium arsenite, and increased GSH levels, without alteration in the phosphorylation levels of p38 and of its direct target, MAPKAPK-2. These results demonstrate the high efficacy of S. jambos extract in free radical-scavenging, and inhibition of reactive oxygen species.

蒲桃叶片提取物的HPLC-PDA-MS / MS分析可鉴定出17种次级代谢产物，包括黄酮糖苷，黄酮二糖苷和黄酮以及鞣花单宁和酚酸。提取物在不同的实验模型中显示出有希望的抗氧化活性。在秀丽隐杆线虫中，提取物介导剂量依赖性存活率并降低细胞内ROS水平和HSP-16.2表达。在针对急性CCl ₄的大鼠模型中中毒后，提取物降低了所有测试的肝脏标志物ALT，AST，TB，TC，TG和MDA的水平，并增加了GSH和SOD。效果类似于水飞蓟素。在肝细胞中，用提取物进行预处理可抑制ROS的产生，抵抗亚砷酸钠的有害作用，并增加GSH的水平，而不会改变p38及其直接靶标MAPKAPK-2的磷酸化水平。这些结果证明了桑树链球菌提取物在清除自由基和抑制活性氧方面具有很高的功效。