Due to the idiopathic inflammation of the gastrointestinal tract and ulcerative colitis, there is an increased risk of colorectal cancer in inflammatory bowel disease (IBD) patients. Chemoprevention remains vital and much interest has been focused on targetable inflammatory proteins associated with IBD. Dextran sodium sulfate (DSS) induced colitis mimics human IBD in mouse, which is used as a model to determine the action of Lupeol (a triterpene), found in certain fruits and Indian herbs, in the healing of colitis. DSS causes chronic inflammation of the colonic epithelium by altering mucosal immune system i.e. mucins and inflammatory proteins namely TNF-α, IL 1 and 2 and NF-κB. Lupeol supplement to colitis mice, showed colonic regeneration by altering the MUC 1 & 2 gene expression. Lupeol also modulates TWIST gene expression, NF-κB, mediated inflammation and assists down regulation of TNF-α and IL genes. Thus Lupeol has potent colonic healing activity and also acts as an anti-inflammatory agent in controlling colitis.

由于胃肠道的特发性炎症和溃疡性结肠炎，炎性肠病（IBD）患者的结直肠癌风险增加。化学预防仍然至关重要，并且人们对与IBD相关的可靶向炎症蛋白的关注也很多。硫酸右旋糖酐硫酸钠（DSS）诱导的结肠炎模仿了小鼠中的人IBD，该模型被用作确定在某些水果和印度草药中发现的卢皮醇（​​三萜）在结肠炎愈合中的作用的模型。DSS通过改变粘膜免疫系统（即粘蛋白和炎症蛋白，即TNF-α，IL 1和2和NF-κB）引起结肠上皮的慢性炎症。Lupeol对结肠炎小鼠的补充通过改变MUC 1和2基因表达显示出结肠再生。Lupeol还调节TWIST基因表达NF-κB，介导的炎症，并协助下调TNF-α和IL基因。因此，Lupeol具有有效的结肠愈合活性，并在控制结肠炎中也起着消炎剂的作用。