Multifunctional nanomaterials with simple structure and good biosafety, integrating multimodal imaging and therapeutic functions, can facilitate the development of clinical cancer treatments. Here, a simple but powerful pure bismuth based nanoparticle (Gd-PEG-Bi NPs) was developed from pure Bi NPs and gadolinium-diethylenetriaminepentaacetic acid-bis-tetradecylamide, which not only shows high quality MRI /CT/PAI triple-modal imaging, but can also be a potent photothermal therapy agent under the guidance of the triple-modal imaging. The Gd-PEG-Bi NPs showed good stability and excellent biocompatibility. In vitro and in vivo study demonstrated that Gd-PEG-Bi NPs have ultrahigh X-ray attenuation coefficient, short T1 relaxation time in MRI, and strong PAI signal. Following the imaging diagnosis, the excellent light-to-heat conversion efficiency of Gd-PEG-Bi NPs was capable of suppressing the tumor growth effectively under near-infrared laser radiation in vivo. Such multifunctional nanoparticles were ideal candidates for cancer diagnosis and treatment.

具有简单结构和良好生物安全性的多功能纳米材料，整合了多模式成像和治疗功能，可以促进临床癌症治疗的发展。在这里，从纯Bi NP和and-二亚乙基三胺五乙酸-双十四烷基酰胺开发了一种简单但功能强大的纯铋基纳米颗粒（Gd-PEG-Bi NPs），不仅显示了高质量的MRI / CT / PAI三重模态成像，但在三重模式成像的指导下，它也可以成为有效的光热疗法治疗剂。Gd-PEG-Bi NPs表现出良好的稳定性和优异的生物相容性。体外和体内研究表明，Gd-PEG-Bi NPs具有超高的X射线衰减系数，MRI的T1弛豫时间短和强大的PAI信号。影像学诊断后，Gd-PEG-Bi NPs优异的光热转换效率能够在体内近红外激光辐射下有效抑制肿瘤的生长。这样的多功能纳米颗粒是用于癌症诊断和治疗的理想候选者。