In a paper recently published in Cell Research, Yu et al. identify two MAPK-related kinases, MAPK11 and HIPK3, as positive regulators of levels of mutant huntingtin protein, a toxic species highly involved in Huntington's disease (HD) pathology. The identification and validation of these kinases as therapeutic targets for knockdown in multiple relevant experimental model systems reveal novel potential approaches for treatment of HD.

中文翻译：

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寻找没有MAP（K）的突变体。

Yu等人最近发表在《细胞研究》上的论文中。确定了两种与MAPK相关的激酶MAPK11和HIPK3作为突变亨廷顿蛋白（一种高度参与亨廷顿舞蹈病（HD）病理学）的有毒物种的水平的正调节剂。这些激酶作为多种相关实验模型系统中敲除的治疗靶标的鉴定和验证，揭示了治疗HD的潜在新方法。