Asthma is an oxidative stress related disease, but associations with asthma outcomes are poorly studied in adults. We aimed to study the associations between several biomarkers related to oxidative stress and various asthma outcomes. Cross-sectional analyses were conducted in 1388 adults (mean age 43 years, 44% with asthma) from the Epidemiological Study of the Genetics and Environment of Asthma (EGEA2). Three blood antioxidant enzyme activities (biomarkers of response to oxidative stress) and exhaled breath condensate 8-isoprostanes and plasma fluorescent oxidation products (FlOPs) levels (two biomarkers of damage) were measured. Associations between biomarkers and 1) ever asthma and 2) asthma attacks, asthma control and lung function in participants with asthma were evaluated using regression models adjusted for age, sex and smoking. Biomarkers of response were unrelated to asthma outcomes. Higher 8-isoprostane levels were significantly associated with ever asthma (odds ratio for one interquartile range increase 1.28 (95% CI 1.06–1.67). Among participants with asthma, 8-isoprostane levels were negatively associated with adult-onset asthma (0.63, 0.41–0.97) and FlOPs levels were positively associated with asthma attacks (1.33, 1.07–1.65), poor asthma control (1.30, 1.02–1.66) and poor lung function (1.34, 1.04–1.74). Our results suggest that 8-isoprostanes are involved in childhood-onset asthma and FlOPs are linked to asthma expression. Oxidative stress-related damage seems to be involved in asthma expression and control http://ow.ly/VSxG30fGNuz

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EGEA 研究成人的氧化应激生物标志物和哮喘特征

哮喘是一种与氧化应激相关的疾病，但对成人哮喘结果的相关性研究很少。我们旨在研究与氧化应激相关的几种生物标志物与各种哮喘结果之间的关联。对来自哮喘遗传与环境流行病学研究 (EGEA2) 的 1388 名成人（平均年龄 43 岁，44% 患有哮喘）进行了横断面分析。测量了三种血液抗氧化酶活性（氧化应激反应的生物标志物）和呼出气冷凝物 8-异前列腺素和血浆荧光氧化产物 (FlOPs) 水平（两种损伤生物标志物）。使用针对年龄、性别和吸烟情况调整的回归模型评估了生物标志物与 1) 曾患过哮喘和 2) 哮喘发作、哮喘控制和肺功能之间的关联。反应的生物标志物与哮喘结果无关。较高的 8-异前列烷水平与哮喘史显着相关（一个四分位距的比值比增加 1.28（95% CI 1.06–1.67）。在哮喘参与者中，8-异前列烷水平与成人哮喘呈负相关（0.63、0.41 –0.97) 和 FlOPs 水平与哮喘发作 (1.33, 1.07–1.65)、哮喘控制不佳 (1.30, 1.02–1.66) 和肺功能不良 (1.34, 1.04–1.74) 呈正相关。我们的结果表明 8-异前列烷是参与儿童期哮喘和 FlOPs 与哮喘表达有关。氧化应激相关损伤似乎与哮喘表达和控制有关 http://ow.ly/VSxG30fGNuz 97）和 FlOPs 水平与哮喘发作（1.33、1.07-1.65）、哮喘控制不佳（1.30、1.02-1.66）和肺功能差（1.34、1.04-1.74）呈正相关。我们的结果表明 8-异前列烷与儿童期哮喘有关，而 FlOP 与哮喘表达有关。氧化应激相关损伤似乎与哮喘表达和控制有关 http://ow.ly/VSxG30fGNuz 97）和 FlOPs 水平与哮喘发作（1.33、1.07-1.65）、哮喘控制不佳（1.30、1.02-1.66）和肺功能差（1.34、1.04-1.74）呈正相关。我们的结果表明 8-异前列烷与儿童期哮喘有关，而 FlOP 与哮喘表达有关。氧化应激相关损伤似乎与哮喘表达和控制有关 http://ow.ly/VSxG30fGNuz