In this work, for the first time, manganese (IV) oxide-modified screen-printed graphene electrodes (MnO2/SPGEs) were developed for the simultaneous electrochemical detection of coenzyme Q10 (CoQ10) and α-lipoic acid (ALA). This sensor exhibits attractive benefits such as simplicity, low production costs, and disposability. Cyclic voltammetry (CV) was used to characterize the electrochemical behavior of the analyte and investigate the capacitance and electroactive surface area of the unmodified and modified electrode surfaces. The electrochemical behavior of CoQ10 and ALA on MnO2/SPGEs was also discussed. Additionally, square wave anodic stripping voltammetry (SWASV) was used for the quantitative determination of CoQ10 and ALA. Under optimal conditions, the obtained signals are linear in the concentration range from 2.0 to 75.0 μg mL-1 for CoQ10 and 0.3-25.0 μg mL-1 for ALA. The low limits of detection (LODs) were found to be 0.56 μg mL-1 and 0.088 μg mL-1 for CoQ10 and ALA, respectively. Moreover, we demonstrated the utility and applicability of the MnO2/SPGE sensor through simultaneous measurements of CoQ10 and ALA in dietary supplements. The sensor provides high accuracy measurements, exhibiting its high potential for practical applications.

中文翻译：

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使用氧化锰 (IV) 修饰的丝网印刷石墨烯电极同时测定辅酶 Q10 和 α-硫辛酸的低成本和一次性传感器

在这项工作中，首次开发了氧化锰 (IV) 修饰的丝网印刷石墨烯电极 (MnO2/SPGEs)，用于同时电化学检测辅酶 Q10 (CoQ10) 和 α-硫辛酸 (ALA)。该传感器具有吸引人的优点，例如简单、低生产成本和一次性使用。循环伏安法 (CV) 用于表征分析物的电化学行为，并研究未改性和改性电极表面的电容和电活性表面积。还讨论了 CoQ10 和 ALA 在 MnO2/SPGE 上的电化学行为。此外，方波阳极溶出伏安法 (SWASV) 用于定量测定 CoQ10 和 ALA。在最佳条件下，获得的信号在 2.0 到 75 的浓度范围内呈线性。CoQ10 为 0 μg mL-1，ALA 为 0.3-25.0 μg mL-1。发现 CoQ10 和 ALA 的检测下限 (LOD) 分别为 0.56 μg mL-1 和 0.088 μg mL-1。此外，我们通过同时测量膳食补充剂中的 CoQ10 和 ALA，证明了 MnO2/SPGE 传感器的实用性和适用性。该传感器提供高精度测量，显示出其在实际应用中的巨大潜力。