Across species, many individuals carry one or more recessive lethal alleles, posing an evolutionary conundrum for their persistence. Using a population genomic approach, Amorim et al. studied the abundance of lethal disease-causing mutations in humans and found that, while appearing more common than expected, most may nonetheless persist at frequencies predicted by mutation–selection balance.

中文翻译：

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人类中的致死等位基因太丰富了吗？

在整个物种中，许多个体携带一个或多个隐性致死等位基因，为它们的持久性带来了进化难题。使用种群基因组学方法，Amorim等人。对人类致死性致突变的数量进行了研究，发现尽管出现的突变比预期的更为普遍，但大多数突变可能仍会保持在突变选择平衡所预测的频率上。