Blood components play key roles in the modulation of the wound healing process and, together with the provisional fibrin matrix ability to selectively bind bioactive molecules and control its spatial-temporal presentation, define the complex microenvironment that characterize this biological process. As a biomimetic approach, the use of blood derivatives in regenerative strategies has awakened as a source of multiple therapeutic biomolecules. Nevertheless, and despite their clinical relevance, blood derivatives have been showing inconsistent therapeutic results due to several factors, including proper control over their delivery mechanisms. Herein, we highlight recent trends on the use biomaterials to protect, sequester and deliver these pools of biomolecules in tissue engineering and regenerative medicine approaches. Particular emphasis is given to strategies that enable to control their spatiotemporal delivery and improve the selectivity of presentation profiles of the biomolecules derived from blood derivatives rich in platelets. Finally, we discussed possible directions for biomaterials design to potentiate the aimed regenerative effects of blood derivatives and achieve efficient therapies.

血液成分在伤口愈合过程的调节中起着关键作用，再加上临时的纤维蛋白基质选择性结合生物活性分子并控制其时空表现的能力，定义了表征该生物过程的复杂微环境。作为仿生方法，血液衍生物在再生策略中的使用已被唤醒，成为多种治疗性生物分子的来源。尽管如此，尽管它们具有临床相关性，但由于多种因素，包括对它们的递送机制的适当控制，血液衍生物一直显示出不一致的治疗效果。在本文中，我们重点介绍了在组织工程和再生医学方法中使用生物材料保护，隔离和交付这些生物分子库的最新趋势。特别强调了能够控制其时空传递并提高衍生自富含血小板的血液衍生物的生物分子的表达谱的选择性的策略。最后，我们讨论了生物材料设计的可能方向，以增强血液衍生物的目标再生效果并实现有效的治疗方法。