The selection of the right drug targets is critically important for the successful and cost-effective development and clinical testing of drugs. A 2009 paper reported an in silico prospective prediction of the clinical potential of 156 targets of clinical trial drugs (all of these targets were without an approved drug at the time of the paper’s publication). Eight years later, the assessment of the clinical status of these targets revealed impressive capability of the in silico method in prospectively predicting the clinical success of drug targets.

中文翻译：

---

In silico研究预测的药物靶标的临床成功

选择正确的药物靶标对于成功且具有成本效益的药物开发和临床测试至关重要。2009年的一篇论文报告了对156种临床试验药物靶标的临床潜力进行的计算机模拟前瞻性预测（在本文发表时，所有这些靶标均未获得批准的药物）。八年后，对这些靶标临床状态的评估揭示了计算机方法在前瞻性预测药物靶标临床成功方面的出色能力。