Flavones are present in a variety of medicines and natural products and are important structural motif due to their unique mode of physiological action. Hence the structural importance of flavone moiety has elicited a great deal of interest in the field of organic synthesis and chemical biology to develop some new and improved synthesis of this molecular skeleton. Herein, we have described an up to date overview on the recent advances in the diverse synthetic methodologies of flavones. The review covers the basic conceptual and practical catalytic synthesis like carbonylative annulation, cyclodehydration, Suzuki Miyaura coupling, Heck coupling, green methodologies, metal catalyzed reactions, organocatalytic transformations, microwave irradiation, etc. which are significant for constructing flavone skeleton. This review will satisfy the expectations of readers who are interested in the development of the field and looking for an update. It will stimulate researchers to develop new and creative synthetic access to this heterocyclic system, which will be instrumental in the advancement of flavone chemistry.

黄酮存在于多种药物和天然产物中，由于其独特的生理作用方式，它们是重要的结构基序。因此，黄酮部分的结构重要性引起了有机合成和化学生物学领域的极大兴趣，以开发这种分子骨架的一些新的和改进的合成方法。在本文中，我们描述了有关黄酮的各种合成方法学的最新进展的最新概述。审查涵盖了基本的概念和实际的催化合成，如羰基环化，环脱水，铃木宫浦偶联，Heck偶联，绿色方法，金属催化的反应，有机催化的转化，微波辐射等，这些对构建黄酮骨架具有重要意义。这篇评论将满足对该领域的发展感兴趣并寻求更新的读者的期望。这将刺激研究人员开发出对该杂环系统的新颖且合成的合成途径，这将有助于黄酮化学的发展。