Palladium-catalyzed diastereoselective synthesis of optically active β,β-diarylpropionic acid derivatives employing 4-(tert-butyl)oxazolidin-2-one as the chiral auxiliary under an air atmosphere in excellent yields with high diastereoselectivity is reported. The catalytic system is applied to the total synthesis of (R)-tolterodine and the enantiomer of a key intermediate for MK-8718.

中文翻译：

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钯催化的β，β-二芳基丙酸衍生物的非对映选择性合成及其在（R）-托特罗定和MK-8718关键中间体对映体的总合成中的应用

报道了在空气气氛下以4-（叔丁基）恶唑烷-2-酮为手性助剂的钯催化的非对映选择性合成光学活性的β，β-二芳基丙酸衍生物，其具有非对映选择性高的产率。该催化体系用于（R）-托特罗定和MK-8718关键中间体对映异构体的全合成。