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Pyridone alkaloids from the scale-insect pathogenic fungus Hypocrella discoidea BCC 71382
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2017-12-30 , DOI: 10.1016/j.tetlet.2017.12.084 Masahiko Isaka , Rachada Haritakun , Suchada Mongkolsamrit , Sumalee Supothina , Tao Feng , Ji-Kai Liu
中文翻译:
鳞状病原真菌盘状菌Hypocrella discoidea BCC 71382的吡啶酮生物碱
更新日期:2017-12-30
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2017-12-30 , DOI: 10.1016/j.tetlet.2017.12.084 Masahiko Isaka , Rachada Haritakun , Suchada Mongkolsamrit , Sumalee Supothina , Tao Feng , Ji-Kai Liu
Hypocrellutins A–C (1–3), 2- and 4-pyridone alkaloids, were isolated from cultures of the scale-insect pathogenic fungus Hypocrella discoidea BCC 71382. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. The absolute configuration of hypocrellutin B (2) was determined by ECD calculation. Their plausibly biosynthetic pathways are proposed. All isolated compounds were inactive in the antifungal, antimalarial, antitubercular, and cytotoxic activity assays.
中文翻译:
鳞状病原真菌盘状菌Hypocrella discoidea BCC 71382的吡啶酮生物碱
Hypocrellutins A-C(1 - 3),2-和4-吡啶酮生物碱,是从鳞片昆虫致病性真菌的培养物中分离Hypocrella discoidea BCC 71382.的结构进行了阐明NMR光谱和质谱分析数据的基础上。通过ECD计算确定了降乳素B(2)的绝对构型。他们似乎合理的生物合成途径被提出。所有分离的化合物在抗真菌,抗疟疾,抗结核和细胞毒性活性测定中均无活性。