Fe₃O₄@CeO₂ yolk–shell nanocomposites (NCs) were synthesized by growing CeO₂ onto Fe₃O₄ hollow nanoparticles (NPs) as an artificial peroxidase for the purpose of elevated activity. The resultant NCs exhibited strong magnetic response with narrow size distribution and high surface area. Owing to the individual peroxidase-like catalytic activity of CeO₂ onto Fe₃O₄ nanoparticles (NPs), Fe₃O₄@CeO₂ NCs was investigated to achieve synergistic catalytic activity. As a result, the as-prepared Fe₃O₄@CeO₂ NCs exhibited impressive peroxidase-like catalysis activity for 3, 3′, 5, 5′-tetramethylbenzidine (TMB). Moreover, comparing with natural enzymes, hollow Fe₃O₄ NPs and CeO₂ NPs, the Fe₃O₄@CeO₂ NCs displayed a lower Michaelis constant (K_m) value or stronger affinity to H₂O₂ and TMB. A limit of detection of 8.5 µmol/L for H₂O₂ and 21 µmol/L for glucose was attained with acceptable stability and reproducibility. The activation mechanism was also studies using competitive radical tests and Electron spin resonance (ESR) analysis.

Fe ₃ O ₄ @CeO ₂卵黄壳纳米复合材料（NCs）是通过将CeO ₂生长在Fe ₃ O ₄空心纳米颗粒（NPs）上作为人工过氧化物酶而合成的，目的是提高活性。所得的NC显示出强的磁响应，具有窄的尺寸分布和高的表面积。由于CeO ₂对Fe ₃ O ₄纳米颗粒（NPs）具有类似过氧化物酶的催化活性，因此对Fe ₃ O ₄ @CeO ₂ NCs进行了研究以达到协同催化活性。结果，制备的Fe ₃ O ₄@CeO ₂ NCs对3，3'，5，5'-四甲基联苯胺（TMB）表现出令人印象深刻的过氧化物酶样催化活性。此外，与天然酶，空心Fe ₃ O ₄ NP和CeO ₂ NPs相比，Fe ₃ O ₄ @CeO ₂ NCs的Michaelis常数（K _m）值更低，或与H ₂ O ₂和TMB的亲和力更强。H ₂ O ₂的检出限为8.5 µmol / L葡萄糖达到21 µmol / L，并具有可接受的稳定性和可重复性。还使用竞争性自由基测试和电子自旋共振（ESR）分析研究了激活机制。