Over the past years, basic findings in cancer research have revealed metabolic symbiosis between different cell types to cope with high energy demands under limited nutrient availability. Although this also applies to regenerating tissues with disrupted physiological nutrient and oxygen supply, the impact of this metabolic cooperation and metabolic reprogramming on cellular development, fate, and function during tissue regeneration has widely been neglected so far. With this review, we aim to provide a schematic overview on metabolic links that have a high potential to drive tissue regeneration. As bone is, aside from liver, the only tissue that can regenerate without excessive scar tissue formation, we will use bone healing as an exemplarily model system.

中文翻译：

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代谢微环境引导骨组织再生

在过去的几年里，癌症研究的基本发现揭示了不同细胞类型之间的代谢共生，以应对营养供应有限的情况下的高能量需求。尽管这也适用于生理营养和氧气供应中断的组织再生，但迄今为止，这种代谢合作和代谢重编程对组织再生过程中细胞发育、命运和功能的影响已被广泛忽视。通过这篇综述，我们旨在提供一个关于具有驱动组织再生潜力的代谢联系的示意图。由于骨骼是除肝脏之外唯一可以再生而不会形成过多疤痕组织的组织，因此我们将使用骨骼愈合作为示例性模型系统。